Figure 2.
Classes and frequencies of mosaic sequences possible from mismatch repair of heteroduplex containing three mismatches. (A) Mismatch repair of unmethylated heteroduplexes containing three mismatches can generate three classes of mosaic sequences: (i) restoration of an original sequence, (ii) creation of mosaics with distinct domains at the 3′ and 5′ ends and (iii) creation of mosaics with related insert termini but internal hybridism. (B) Relative frequencies of the mosaic classes produced by MutHLS repair of one heteroduplex containing three mismatches are indicated for independent repair of each mismatch or for co-repair of adjacent mismatches where repair initiates only at nick sites flanking the heteroduplex insert.