Fig. 6.
Restoring P-glycoprotein in hAPP mice reduces Aβ levels in brain capillaries. A and B, representative images of hAβ40-immunostained (A) and hAβ42-immunostained (B) brain capillaries from vehicle- and PCN-treated hAPP mice. C and D, data from membrane hAβ-immunofluorescence analysis. Data are mean ± S.E.M. for 10 capillaries (pooled tissue from 20 mice per group). Shown are arbitrary fluorescence units (scale 0–255). *, significantly lower than control, P < 0.05; **, significantly lower than control, P < 0.01. E, hAβ40 and hAβ42 Western blots of brain capillary membranes.