Table 3.
T Lymphocyte Marker Localization and DNA Mismatch Repair (MMR) Status.
| Intraepithelial | Stromal | Intraepithelial/Stromal | |
|---|---|---|---|
| FoxP3+ | |||
| MMR – Deficient (n=13) | 1.4 | 21.0 | 0.15 |
| MMR – Proficient (n=112) | 1.0 | 19.8 | 0.031 |
| P-value2 | 0.053 | 0.512 | 0.012 |
| CD3+ | |||
| MMR – Deficient (n=13) | 16.0 | 39.0 | 0.44 |
| MMR – Proficient (n=112) | 6.0 | 34.5 | 0.16 |
| P-value2 | 0.064 | 0.903 | 0.069 |
| CD3+/FoxP3+ ratio | |||
| MMR – Deficient (n=10) | 5.1 | 1.93 | 3.0 |
| MMR – Proficient (n=68) | 5.0 | 1.83 | 3.8 |
| P-value2 | 0.545 | 0.740 | 0.714 |
| CD8+ | |||
| MMR – Deficient (n=13) | 29.2 | 72.4 | 0.43 |
| MMR – Proficient (n=13) | 7.6 | 77.2 | 0.11 |
| P-value2 | 0.281 | 0.538 | 0.383 |
| CD25+ | |||
| MMR – Deficient (n=12) | 10.7 | 26.0 | 0.38 |
| MMR – Proficient (n=13) | 2.0 | 44.8 | 0.05 |
| P-value2 | 0.005 | 0.028 | 0.0001 |
Median values of a calcuated index are shown (see Methods).
1
Wilcoxon Rank-Sum test.
2
3 cases excluded due to 0 values in the denominators.
3
13 MMR-deficient, 109 MMR-proficient.