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. 2012 Feb 8;37(6):1377–1386. doi: 10.1038/npp.2011.323

Figure 3.

Figure 3

Extinction (a) and reinstatement (b–d) of cocaine seeking in experiment 1. During extinction (panel a), high-impulsive (HI) rats were more resistant to extinction than were low-impulsive (LI) rats (session*impulsivity: #p<0.05). However, in both HI and LI animals, active lever responding decreased over sessions (session: **p<0.001). Both HI and LI animals showed a context-induced reinstatement response (session: **p<0.001) and this was stronger in HI than in LI animals (panel b, session*impulsivity: #p<0.05). Both cocaine (panel c, 10 mg/kg) and yohimbine (panel d, 1.25 mg/kg) induced reinstatement of cocaine seeking, but these effects did not differ between HI and LI animals (session: *p<0.05, **p<0.001).

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