Figure 2. Primary transporters in the neurovascular unit.
The spatial and cellular relationships of the transporters are shown. Only proteins detected at the protein level are depicted. For a more complete listing of carrier-mediated transport systems at the blood-brain interface see Ohtsuki and Terasaki38. The following acronyms are used: BCRP, breast cancer resistance protein; GLUT1, glucose transporter-1; LRP, low-density lipoprotein receptor-related protein; MCT, monocarboxylic acid transporter; Mrp, multidrug resistance protein; Oat, organic anion transporter; Oatp, organic anion transporting protein; P-gp, P-glycoprotein; RAGE, receptor for advanced glycation end products; RLIP76, Ral-binding protein-1. Modified, with permissions, from Refs. 80 and 161.