Table 1.
Effects of brief maternal separation (≤ 15 min) on drug abuse-related behaviors in rodents
| Model* | Drug | Dose | Effect** | References*** |
|---|---|---|---|---|
| CPP | Amphetamine | 2–5 mg/kg, i.p. | ↓ amphetamine-CPP | Campbell and Spear, 1999 |
| Self- administration | cocaine | 0.5–1.0 mg/kg, i.v. | ↓ cocaine intake | Flagel et al, 2003 (only males and only when handled during the 1st and not 2nd post-natal week); Moffett et al, 2006(Weinberg 1987) |
| 0.5–1.0 mg/kg, i.v. | ↑ cocaine intake | Flagel et al, 2003 (only in females and only when handled during the 2nd and not 1st post-natal week) | ||
| Ethanol | 2–10%, oral | ↓ ethanol preference and/or intake |
Hilakivi-Clarke et al, 1991; Jaworski et al, 2005 (NH but not AFR controls); Ploj et al, 2003a (effect in subgroup of high drinkers but not overall); Roman et al, 2003; 2005 (only in alcohol-preferring females) | |
| 2–20%, oral | Ø ethanol preference and/or intake |
Daoura and Nylander, 2011; Daura et al, 2011; Huot et al, 2001; Gustafsson and Nylander, 2006; Gustafsson et al, 2005; 2007; Oreland et al, 2011; Roman et al, 2004 | ||
| ↑ ethanol intake | Lancaster et al, 1998 (adolescent onset in males; adult onset in females) |
*
Controls were either AFR, NH, or MS0 unless otherwise specified
**
Ø represents no effect
***
Annotations refer to comparisons made within the cited reference