Table 5.
Prosocial interactions occurring within the drug context on drug abuse-related behaviors in rodents
| Model | Drug | Dose | Effect | Type of social interaction | References |
|---|---|---|---|---|---|
| Self-administration | Amphetamine | 0.1 mg/kg, i.v. | ↑ amphetamine intake |
Conspecific behind Plexiglas wall | Gipson et al, 2011b |
| Nicotine | 0.015 mg/kg, i.v. | ↑ nicotine intake (males only) |
Conspecific self-administering in chamber with mesh separating wall |
Peartree et al, 2011 | |
| 0.015 mg/kg, i.v. | ↓ nicotine intake (females only) |
Conspecific self-administering in chamber with mesh separating wall |
Peartree et al, 2011 | ||
| 15–30 µg/kg, i.v. | ↑ nicotine intake | Conspecific self-administering olfactory- gustatory drug-CS in chamber with perforated Plexiglas separating wall |
Chen et al, 2011 | ||
| Ethanol* | 3–10%, oral | ↑ ethanol intake | Social-conditioned cue (scent of ethanol on intoxicated conspecific) |
Hunt et al, 2000, 2001; Maldonado et al, 2008 |
|
| CPP | Methamphetamine | 2 mg/kg, i.p. | ↑ amphetamine CPP | Drug +conspecific US during conditioning |
Watanabe, 2011 (only if conspecific is in similar drug state) |
| Cocaine | 2 mg/kg, i.p. | ↑ cocaine CPP | Drug +conspecific US during conditioning | Thiel et al, 2008 | |
| Nicotine | 0.1 mg/kg, s.c. | ↑ nicotine CPP | Drug +conspecific US during conditioning | Thiel et al, 2009a | |
| Morphine | 0.25–5 mg/kg, s.c. | ↑ morphine CPP | Drug +conspecific US during conditioning |
Kennedy et al, 2011 (anti-social strain of mice) |
|
| ↓ morphine CPP | Drug +conspecific US during conditioning |
Kennedy et al, 2011 (social strain of mice) |
|||
| Ethanol | 4 g/kg 20%, oral | ↓ ethanol CPA | Drug +conspecific US during conditioning | Gauvin et al, 1994 | |
| CPP-like procedure | Ethanol | ↑ approach to ethanol cue |
Social-conditioned cue (scent of ethanol on intoxicated conspecific) |
Fernandez-Vidal & Molina, 2004 |
*
Choice ethanol consumption