Figure 5. Co-expression of MYC and PIM kinases drives myeloid leukemia.
(A) Splenocytes (Sp.), thymocytes (Thy.) and bone marrow (BM) were prepared from four representative MYC + PIM1 mice and a non-manipulated FVB mouse. Cells were stained with the Ly-6G/Ly-6C (GR-1) and CD11b (Mac-1) antibodies and analyzed by FACS. (B) Comparison of splenocytes from 3 representative mice from each genotype; MYC + BCLxl, MYC + PIM1, MYC + PIM2, MYC + PIM3 stained with Ly-6G/Ly-6C (GR-1) and CD11b (Mac-1) antibodies and analyzed by FACS.