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AZD8931 limits AZD5363-induced phosphorylation of HER2/HER3 and results in more prominent shutdown of the PI3K pathway. (A) BT474c or HCC1954 cells were treated for 24 h with increasing concentrations of AZD5363 ±0.3 μM or 1 μM AZD8931, respectively. Protein lysates were analysed by immunoblot with the indicated antibodies. Blots are representative of blots from 2–3 separate experiments. (B) Comparison of synergy scores for the combination of AZD5363 with either AZD8931 or AZD6244.
