Figure 2. Maximum Percent Change from Baseline in the Sum of the Diameters of Target Lesions.
The change from baseline in the target lesion diameter is shown for patients who had measurable disease at baseline according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, and who underwent at least one post-treatment evaluation; dashed lines indicate −30% change, the minimum necessary to qualify for partial response according to RECIST. Data are shown for 18 patients in the NSCLC cohort (Panel A), 26 patients in the colorectal cancer cohort who were treated with vemurafenib plus cetuximab (Panel B), and patients in the all-others cohort (i.e., patients with tumor types that were not prespecified) plus 1 patient with low-grade serous ovarian cancer (Panel C). The tumor types in the all-others cohort included gliomas, head and neck cancer, pancreatic cancer, pleomorphic xantho-astrocytoma, esophageal and gastric cancers, sarcoma, and carcinoma of unknown primary type. Five patients (1 in the NSCLC cohort and 4 in the all-others cohort) died before evaluation. Asterisks indicate patients in the dose-escalation stage (dose levels 1 and 2).