Rodrigo B Leal

Universidade Federal de Santa Catarina - UFSC (Federal University of Santa Catarina), Bioquímica, Professor Titular

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Address: Universidade Federal de Santa Catarina (UFSC)
Departamento de Bioquímica,
Centro de Ciências Biológicas (CCB),
Campus Universitário, Florianópolis, SC

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James Elkins

School of the Art Institute of Chicago

Elana Fertig

Johns Hopkins University

Zhe (Jenny) Zhang

Mayo Clinic

Andrew Reynolds

Cape Breton University

Manlio Vinciguerra

University College London

Renat Shaykhiev

Cornell University

Hernan Chaimovich

Universidade de São Paulo

Marcin Józef Suskiewicz

Centre National de la Recherche Scientifique / French National Centre for Scientific Research

Peixin Dong

Hokkaido University

Benoit Roux

University of Chicago

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Chapter 7. Effect of Manganese on Signaling Pathways

Issues in Toxicology

A complex intercellular and intracellular signaling network modulates the main neural functions. ... more A complex intercellular and intracellular signaling network modulates the main neural functions. Regulation of protein kinases and protein phosphatases activities modify the phosphorylation state of target proteins that direct a diversity of cell fates, including gene expression, neural cell migration, differentiation or proliferation, cell survival or death, and synaptic plasticity. Regardless of all these aspects, modulation of intracellular signaling pathways by toxicants has only recently become part of the molecular toxicology research. Manganese (Mn) exposure causes a neurological syndrome, manganism, which resembles Parkinson's disease. The mechanisms of Mn neurotoxicity are not completely clear but may involve mitochondrial dysfunctions, induction of oxidative stress, and alterations in dopaminergic system, especially in the basal ganglia. The modulation of intracellular cell signaling elements by Mn and the cell fates of these effects is an issue that requires attention. In this chapter, we will present cell signaling pathways dependent of protein kinases (e.g. PKA, PKC, MAPKs, AKT, and GSK3β) and protein phosphatases (e.g. PP1 and PP2A) that have been reported to be altered in response to Mn exposure. Since only a few studies have addressed these aspects in vivo, a series of data obtained in vitro from cell cultures exposed to Mn will also be presented, aiming to help us identify the possible sites of Mn action in cell signaling networks involved in the patophysiology of Mn neurotoxicity.

ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation

Biochimie, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Rodrigo B Leal

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