Kelly Preston was born on October 13, 1962 in Honolulu, Hawaii. A talented and captivating performer, she first garnered international attention with her role as "Marnie Mason" in Ivan Reitman's Twins (1988), starring Arnold Schwarzenegger and Danny DeVito. With her diverse character portrayals in films, such as director Cameron Crowe's Jerry Maguire (1996); Citizen Ruth (1996) for Alexander Payne; and For Love of the Game (1999), directed by Sam Raimi, she continued to capture audience attention.

In the early part of her career, Kelly worked with notable director John Frankenheimer in the Elmore Leonard film, 52 Pick-Up (1986), alongside Roy Scheider and Ann-Margret. Her career saw her cast her beside some of Hollywood's most notable names, including Kevin Spacey in Casino Jack (2010); Quentin Tarantino, George Clooney, and Harvey Keitel in Robert Rodriguez's From Dusk Till Dawn (1996); Kevin Bacon in Death Sentence (2007); Meg Ryan and Matthew Broderick in Addicted to Love (1997); Debra Winger, Zooey Deschanel, and Hank Azaria in Eulogy (2004); Mike Myers in The Cat in the Hat (2003); and Rod Steiger and Julie Harris in the Academy Award-nominated short, Little Surprises (1996).

Kelly was actively involved in education, drug reform and many charitable organizations. She was acknowledged with numerous awards as a result of her work. She married John Travolta on September 12, 1991, and they had three children.

Kelly died on July 12, 2020, in Ocala, Florida, after a two-year battle with breast cancer. She was 57.