- He is the only actor to be nominated for the Saturn Award for Best Supporting Actor twice in the same year, for both Star Trek: First Contact (1996) and Independence Day (1996); he won for the former.
- He is one of two actors, the other being Patrick Stewart Star Trek: The Next Generation (1987) regular to share scenes with all three original Star Trek (1966) series cast members who appeared on that series: DeForest Kelley, Leonard Nimoy and James Doohan.
- Changed his last name to Mintz at about age six, readopted Spiner as a stage name at about age 20.
- He was a groomsman at Marina Sirtis' wedding, and served as best man at Patrick Stewart's wedding.
- Along with Jonathan Frakes, Marina Sirtis, Michael Dorn, Colm Meaney and Jeffrey Combs, he is one of only six actors to appear in the series finales of two different "Star Trek" series (Star Trek: The Next Generation (1987) and Star Trek: Enterprise (2001)).
- Has played five different members of the Soong family on "Star Trek": Lieutenant Commander Data in Star Trek: The Next Generation (1987), Star Trek: Generations (1994), Star Trek: First Contact (1996), Star Trek: Insurrection (1998), Star Trek: Nemesis (2002) and Star Trek: Enterprise (2001); Dr. Noonien Soong and Lore in Star Trek: The Next Generation (1987); B-4 in Star Trek: Nemesis (2002); and Dr. Arik Soong in Star Trek: Enterprise (2001). Data, Lore and B-4 were all androids made in Dr. Noonien Soong's image and Dr. Arik Soong was his great-grandfather.
- His character, Lt. Commander Data's line "Intriguing!" went down in Trek history as replacing Mr. Spock's world-famous line "Fascinating!".
- Attended and graduated from the University of Houston in Houston, Texas (1974).
- Has one son: Jackson Spiner (born June 29, 2002).
- He starred as John Adams in the Broadway revival of "1776" for which he received a Drama Desk Award nomination for best performance by a lead actor in a musical.
- Godfather of Gates McFadden's son James Cleveland.
- His parents, Sylvia (Schwartz) and Jack Spiner, were both from Jewish immigrant families (from Austria, Hungary and Russia).
- In October 2004, he began three guest appearances on Star Trek: Enterprise (2001) as Arik Soong, an ancestor of Noonien Soong, the creator of Data, his character from Star Trek: The Next Generation (1987). He also played Noonien Soong in Brothers (1990) and Inheritance (1993).
- Released the album "Ol' Yellow Eyes is Back" (based on an old crooner song of the 1940s) with his male co-stars from Star Trek: The Next Generation (1987) singing backup vocals. The album's title refers to Data, whom he plays on the series.
- Has played a fictional character, James Campbell, on Friends (1994) and himself on the spin-off series Joey (2004).
- Has appeared with Erick Avari in three different productions: Star Trek: The Next Generation (1987), Independence Day (1996) and The Master of Disguise (2002).
- Has played the same character (Lt. Commander Data) on three different series: Star Trek: The Next Generation (1987), Star Trek: Enterprise (2001) and SpongeBob SquarePants (1999).
- Has appeared in three science fiction films in 1996: Phenomenon (1996), Independence Day (1996) (released on the same day), and Star Trek: First Contact (1996).
- Has appeared in episodes of three different series with Jonathan Frakes and Marina Sirtis: Star Trek: The Next Generation (1987), Gargoyles (1994) and Star Trek: Enterprise (2001).
- When added to the Broadway cast of "Big River: The Adventures of Huckleberry Finn", he replaced another future Star Trek actor: Rene Auberjonois.
- Has appeared on Star Wars: Rebels (2014), making him the first Star Trek actor to appear on the animated series, soon to be followed by Clancy Brown and Simon Pegg.
- Attended and graduated from Bellaire High School in Bellaire, Texas (1968).
- He was the only Houstonian, and for that matter, the only Texan, who appears in The Aviator (2004), whose subject, Howard Hughes, was born in Houston.
- He was considered for the role of the Master in the television movie Doctor Who: The Movie (1996), which went to Eric Roberts.
- He's a fan of Laurel and Hardy.
- Genre enthusiasts liken Spiner's Data to another intelligent golden automaton: C-3PO of the Star Wars trilogies.
- Was an impostor on a 1972 episode of "To Tell The Truth". He was impersonating a coronet playing cabbie and fooled no one. YouTube "Brent Spiner on To Tell The Truth (1972).
- Is a southpaw. (he's left handed).
- Brent Spiner's photograph appears in an exhibit in the Museum of the Southern Jewish Experience in New Orleans, Louisiana--a wall of photos highlighting Jewish Southerners who have made contributions to arts, literature, drama and film, sports, and other cultural endeavors. Other people whose pictures appear in the same exhibit include the actors Ginnifer Goodwin, Tony Randall, Tim Blake Nelson, and Evan Rachel Wood, playwrights Lillian Hellman and Tony Kushner, culinary historian Michael Twitty, and singers Dinah Shore and Kinky Friedman.
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