Elizabeth Ann Perkins was born on November 18, 1960, in the borough of Queens, New York, and was raised in Vermont. Her mother, Jo Williams, was a concert pianist and drug treatment counselor, and her father, James Perkins, was a businessman, farmer, and writer. She is of Greek and English descent. Perkins studied acting at Chicago's Goodman School of Drama at DePaul University for three years, then launched her professional career with a co-starring gig in the touring company of Neil Simon's Brighton Beach Memoirs (1986). Seasoned, she returned to New York in the spring of 1984 to make her Broadway debut as a replacement in the Simon play. As a stage actress, she has trod the boards with Playwrights Horizon, the Ensemble Studio, The New York Shakespeare Festival, and, back in Chicago, with the Steppenwolf Theater. Elizabeth Perkins was listed as one of the 12 "Promising New Actors of 1986" in John Willis' Screen World, and has since landed numerous film roles. Perkins made her film debut in 1986 in Edward Zwick's About Last Night... with Rob Lowe, Demi Moore and Jim Belushi, and had a career breakthrough co-starring with Tom Hanks in Big. She received critical acclaim for her performance in Barry Levinson's Avalon,[9] and was a standout opposite William Hurt in The Doctor (1991), receiving critical acclaim for her performance as a terminal cancer patient.[5] .[10] She subsequently starred in the Alan Rudolph film Love at Large and Sweethearts Dance with Susan Sarandon and Jeff Daniels. Since, she has appeared in Miracle on 34th Street with Sir Richard Attenborough, 28 Days opposite Sandra Bullock, the suspense thriller, The Ring Two, opposite Naomi Watts, Indian Summer with Diane Lane and Bill Paxton, Moonlight and Valentino with Gwyneth Paltrow, Whoopi Goldberg, Kathleen Turner and Jon Bon Jovi, the Antonio Banderas directed Crazy in Alabama opposite Melanie Griffith, Jiminy Glick in LaLaWood with Martin Short, Wilma Flintstone opposite John Goodman in the 1994 live-action comedy The Flintstones, The Thing About My Folks with Paul Reiser and Peter Falk, He Said, She Said with Kevin Bacon and Sharon Stone and Must Love Dogs with John Cusack, Diane Lane, Christopher Plummer, Dermot Mulroney and Stockard Channing. From 2005 to 2009, Perkins played Celia Hodes, an alcoholic and image-obsessed parent-teacher association (PTA) mother, alongside Mary-Louise Parker, Kevin Nealon and Justin Kirk on the Showtime series Weeds. Perkins received two Golden Globe nominations for Best Supporting Actress in a TV Series, Miniseries or Made for TV Motion Picture (in 2006 and 2007).[5] and was also nominated three times for an Emmy Award for Best Supporting Actress in a Comedy Series for her work on Weeds.[5] At a screening of Weeds at the Museum of TV and Radio on October 25, 2006, Perkins said that she considers Celia Hodes her favorite role in her career.[5] On May 6, 2010, she announced that the fifth season of Weeds was her last despite the cliffhanger her character had in the season finale.[11] Perkins appeared in the television projects My Sisters Keeper with Kathy Bates, If These Walls Could Talk with Vanessa Redgrave and Paul Giamatti and Rescuers: Stories of Courage: Two Women directed by Peter Bogdonavich. Perkins starred in the ABC comedy series How to Live with Your Parents (For the Rest of Your Life).[12] with Brad Garrett, played Birdie in the Netflix original series GLOW with Alison Brie, starred as Marilyn Lovell in HBO's epic From The Earth to the Moon, played opposite Amy Adams and Patricia Clarkson in HBO's Sharp Objects directed by Jean-Marc Vallee, starred with Octavia Spencer, Aaron Paul and Lizzie Caplan in AppleTV's Truth Be Told, was featured on HBO's Curb Your Enthusiasm and is currently starring in Season 2 of the Fox comedy The Moodys opposite Denis Leary and Jay Baruchel. She plays the role of Mandy Moores mother on the hit series This Is Us. (Perkins also had a role in the 2003 film Finding Nemo, voicing Coral, the wife of Marlin and mother of Nemo, and who was killed and eaten by the barracuda in the beginning of the film.)