Gregg has worked steadily in film and television for over 30 years. He has played roles in films directed by Mel Brooks, Clint Eastwood, the Coen Brothers, and Woody Allen. He was first discovered while waiting tables in character at the popular Beverly Hills 50's-themed diner, Ed Debevics where he worked as the "security guard" Barney Fife. Rick Dees saw him there and put him on his late night show on ABC, Into the Night with Rick Dees. Gregg was a series regular for the one year run of the show. He later went on to star as Harold Skolnick in the films Revenge of the Nerds 3 and 4. Soon after, Gregg was cast as "Dan the Del Taco Guy" in the very successful advertising campaign that lasted six years and covered 58 television commercials and many more radio spots and personal appearances. During that time Gregg also portrayed Don Knotts in the NBC movie of week Behind the Scenes of Three's Company. Later, he was cast as Kenny James in the Emmy award winning pilot episode of the NBC hit show My Name is Earl. Gregg went on to portray Kenny in 20 episodes during the four year run of the show. Two years later he was cast as a series regular on the hit show, Raising Hope on Fox. Gregg played the grocery store manager Barney Hughes in 71 episodes during the four year run of the show. More recently, Gregg has directed shows for Pure Flix including Hitting the Breaks, Malibu Dan and The Beverlys. His recent acting credits include guest starring roles on NCIS: Los Angeles, Young Sheldon and NCIS. In 2017 he founded Gregg Binkley's "Working Actors Workshop." In 2024 he released the inspirational book GET YOUR ACT TOGETHER: Finding Success in Acting and Life, which has been endorsed by many Emmy award winners including Bryan Cranston, Greg Garcia and Eric Stonestreet. Gregg lives in Los Angeles with his wife and three children.