Alphonse Mouzon's musical associations read like a veritable Who's Who of Modern Jazz and Pop Music. His talents cover a broad range of musical disciplines and philosophies. He was the rhythmic foundation for the far reaching musical explorations of pianist McCoy Tyner. He was a charter member along with keyboardist Joe Zawinul and saxophonist Wayne Shorter, of the group Weather Report. Along with guitarist Larry Coryell, he was co-founder of The Eleventh House, the seminal fusion band of the seventies. The Larry Coryell's Eleventh House reunited after 25 years in July 1998 and toured all over the world featuring Alphonse Mouzon until December 12, 1999.

Mouzon has also played and/or recorded with Gil Evans, Roy Ayers, George Benson, Herbie Hancock, Dizzy Gillespie, Stanley Clarke, Al DiMeola, Les McCann, Ronnie Laws, Klaus Doldinger's Passport, Jaco Pastorius, Ron Carter, Nathan East, Cecil McBee, Albert Mangelsdorff, Joachim Kuhn, Jasper van't Hof, Michel Legrand, Stanley Turrentine, Freddie Hubbard, Hubert Laws, Donald Bird, Chet Baker, Randy Brecker, Michael Brecker, Ernie Watts, Sonny Rollins, Wallace Roney, Arturo Sandoval, Christian McBride, Kenny Barron, Cedar Walton, George Coleman, John Klemmer, Billy Harper, Dave Grusin, Russ Freeman, George Howard, Kirk Whalum, Jeff Lorber, Kenny G., Joanne Brackeen, Horace Parlan, Robin Kenyatta, Ross Carnegie Orchestra, Roberta Flack, Gloria Lynn, Gloria Coleman, Denise Williams, Freda Payne, Shirley Scott, Anita O'Day, Betty Davis, and in 1991, he performed with Miles Davis on the movie soundtrack album entitled "Dingo". Davis even spoke highly of him in his book entitled "Miles - The Autobiography".