This eminently recognizable, bulbous, beetle-browed character actor left Culver Military Academy and began acting in repertory companies before becoming a Hollywood extra and stunt man. Eugene's father had also been a thespian at one time but eventually ended his career as an insurance salesman. In his younger days, Eugene was apparently of the more slender build since he once managed to hold down a job as a jockey! He spent in total six years with touring companies, briefly worked as a streetcar conductor in Portland and finally found his way to motion pictures. By his own account, he began in films on the East Coast around 1910 or 1911, gravitating to Hollywood by 1913 and appeared in some 100 productions each year for the first four years of his tenure. The majority of this prodigious output was undoubtedly made up of one-reel shorts. Eugene initially played leads in silent feature films and was described as relatively athletic by the time he appeared in D.W. Griffith's The Birth of a Nation (1915) and Intolerance (1916). His career was put on hold while he served with the Flying Corps during the First World War, but just a couple of years after his return to films he started to turn into a compulsive gourmand. His vast appetite for food increased his girth manifold and he steadfastly refused to go on a diet. Consequently, he found himself demoted to supporting roles but still managed to make a decent living out of his unusual appearance and his trademark gravelly bullfrog voice. Sometime in the early 1920s, he began to dabble in Texas oil and first amassed and then lost a fortune within the space of a year.

Eugene remained gainfully employed all through the '20s, '30s, and '40s. He played Aramis to Douglas Fairbankss's D'Artagnan in The Three Musketeers (1921) and appeared as a Hal Roach contract player in the classic Laurel & Hardy short The Battle of the Century (1927). In talkies, he was the truculent police sergeant Heath in five installments of the Philo Vance series at Paramount, starring William Powell. When not used as pinstripe-suited authority figures or Runyonesque characters (Nicely-Nicely Johnson in The Big Street (1942)), he was always diverting in screwball comedies, notably in My Man Godfrey (1936) and Topper (1937). A truly versatile, his gallery of characters ranged from garrulous and witty and ingratiating, to brooding loners, from avuncular to cantankerous. Under contract at Warners, he proved to be the very best ever incarnation of Friar Tuck in The Adventures of Robin Hood (1938) and followed this with another priestly effort as Father Felipe in The Mark of Zorro (1940).

Near the end of World War II, Eugene and a business partner acquired a 3500-acre estate and ranch along the Imnaha River in remote Wallowa County, Oregon, complete with a fallout shelter. Allegedly, he lived the life of a semi-recluse for the next four years, anticipating a nuclear attack by stockpiling all manner of essential items in order to become fully self-sufficient. The aforementioned business partner later denied this as a rumor, implying that the ranch was merely a place where Eugene entertained his actor friends (some came to hunt and fish). Whether true or not, Eugene was ultimately forced to sell the property in 1949 due to ill-health (throat cancer, as it turned out). He made his final return to the screen at Poverty Row studio Monogram in Suspense (1946), rounding out his career with a minor film noir set in the skating rink, starring the 'Ice Maiden' Belita. Eugene died eight years later in Los Angeles at the age of 65.