Born in Mexico City on 18 August 1944, Helena Rojo had an extensive career in theater, film and television acting, in both domestic and international productions (notably collaborating with Werner Herzog in "Aguirre, the Wrath of God", as well as Arturo Ripstein in "Fox Trot").

She began her career in the 1960s as a model whilst studying drama, and, in 1968, made her cinematic debut in "El Club de los Suicidas" ("The Suicide Club"), followed in the same year with "Los Amigos" ("Friends"). In 1974, she made her first television appearance as Isaura in the telenovela "Extraño en su Pueblo" ("Stranger in Your Town"). Throughout the 1970s and 1980s, she worked with such renowned and prolific directors in Mexico as Jorge Fons, Rafael Corkidi, Marcela Fernández Violante, and Alberto Bojórquez.

The role that garnered her the most national acclaim was that of Luciana Duval in "El Privilegio de Amar" ("The Privilege of Love"), as well as Juliana in "Abrazame Muy Fuerte" ("Big Hug"), for which she also won a TV y Novelas award for Best Supporting Role. She appeared prominently in "Ramona", a 1999 telenovela. In 2006, she appeared in "Vidas de Fuego", a show-within-a-show featured on the US comedy/drama series "Ugly Betty", portraying Patricia Rivera.