- Tom Hanks credits Joe Spano as his first serious role model and source of inspiration as an actor.
- He and his wife adopted two daughters.
- Was considered for the role of Capt. Donald Cragen on Law & Order (1990).
- Original voice of Pasqually the Chief for the Chuck E Cheese's animatronic show from 1977 to 1983.
- Returned to Berkeley Repertory Theatre after 25 years to co-star in "The Guys" opposite "NYPD Blue" star Sharon Lawrence, in 2003.
- In the early 1970s he appeared nude in a San Francisco production of "Oh, Calcutta!"
- Attended Archbishop Riordan High School in San Francisco.
- As of 2022, he has appeared in three films that were nominated for the Best Picture Oscar: American Graffiti (1973), Apollo 13 (1995) and Frost/Nixon (2008).
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