Callie Thorne is an American actress of Armenian descent. She was born in Boston, and studied theater and dramatic literature at Wheaton College in Norton, Massachusetts. She continued her acting studies at the Lee Strasberg Theatre and Film Institute in New York City.

Thorne made her film acting debut as the female lead in the romantic comedy "Ed's Next Move" (1996). She portrayed the bohemian musician Lee, the love interest of a young scientist who previously had negative experiences in relationships. The film debuted at the 1996 Sundance Film Festival, and was praised by critics for its realism.

Thorne gained her first major television role when cast as detective Laura Ballard in the police procedural series "Homicide: Life on the Street" (1993-1999). Ballard was depicted as a new recruit to the Baltimore Police Department's Homicide Unit, having previously worked as a detective in Seattle. The character joined the series at the start of its 6th season in 1997. Ballard was seriously wounded by gunfire in the penultimate episode of the season. In the 7th and last season of the series, Ballard started dating her co-worker Paul Falsone (played by Jon Seda). Thorne played Ballard for the last time in the spin-off film "Homicide: The Movie" (2000).

In the 2000s, Thorne played recurring characters in several then-popular series. She portrayed the vindictive ex-wife Elena McNulty in the crime drama "The Wire" (2002-2008). The character was initially determined to ruin the life of her former spouse, the police detective Jimmy McNulty (played by Dominic West). They later reconciled, though Elena still did not trust him.

Thorne portrayed the recurring defense attorney Nikki Staines in "Law & Order: Special Victims Unit", starting in 2003. Staines was herself depicted as a sexual assault victim in Season 20 (2019). Thorne portrayed the grieving widow Sheila Keefe in the comedy-drama series "Rescue Me" (2004-2011). The character was suffering from bipolar disorder and substance abuse problems after the death of her husband.

Thorne had the recurring role of the Darfur aide worker Jodie Kenyon in season 12 of the medical drama "ER" (from 2005 to 2006). Thorne portrayed the estranged ex-wife Pamela 'Pam' Larson in several episodes of the crime drama series "Prison Break" (2005-2017). The character was the ex-wife of the troubled FBI agent Alexander "Alex" Mahone (played by William Fichtner).

Thorne had the protagonist role of the therapist Dr. Danielle "Dani" Santino in the drama series "Necessary Roughness" (2011-2013). In the series, Dani is initially struggling financially, so she agrees to become the therapist for an entire professional football team. She soon attracts other high-profile clients. The series deals both with the recurring mental issues of Dani's clients and her own career choices. The series lasted for 3 seasons and a total of 38 episodes.

In 2015, Thorne started appearing in the police procedural "NCIS: New Orleans" (2014-2021). She portrayed the recurring character of Sasha Broussard. Broussard was a member of her family's crime syndicate, and was also a former lover of NCIS agent Dwayne Pride (played by Scott Bakula). Also in 2015, Thorne became a series regular in the second season of the police procedural "The Mysteries of Laura" (2014-2016). She portrayed by-the-book police captain Nancy Santiani, who had an adversarial relationship with her detectives. Santiani's murder was also portrayed in this season.

In 2019, Thorne gained a recurring role in the long-running police procedural "Blue Bloods (2010-). She portrayed the psychic Maggie Gibson, who at times assisted the police with murder cases. Thorne continued portraying the character until 2022. Thorne has had relatively few new roles in the 2020s, though she has not retired from her acting career. She is relatively popular among fans of police procedural series due to her long association with the genre.