Roommates with Ken Marino in college. They were introduced by mutual friend Craig Wedren, who was also his roommate.

Was in an alternate scene of Anchorman: The Legend of Ron Burgundy (2004) with his long-time friend/collaborator Paul Rudd during the Panda Watch: Day 5 report. The scene can be seen on the Unrated version of Anchorman in the Blooper section.

He and Michael Patrick Jann directed almost everything on "The State.".

Originally from the same neighborhood in Ohio as Paul Newman, Fred Willard, & Molly Shannon.

Frequently names female characters in his films "Beth," in honor of his sister, Beth Wain Brandon.

Father of Henry Wain.

Uncle of Samantha Stamler & Alexandra Stamler, daughters of his sister, Cathy Stamler.

Son of Norman Wain & Nina Wain.

Ex-son-in-law of Herbert Hartig.

Ex-brother-in-law of Meg Hartig.