- Arrested for allegedly stalking his ex-wife and stabbing a friend. Was released on $180,000 bail next day. (January 5, 1998)
- Jurors acquitted him of attempted manslaughter in the stabbing of his ex-wife's companion. (September 4, 1998)
- Mykelti is pronounced like "Michael Tee".
- Was an alternate for The Lockers, a featured dance group on Soul Train (1971).
- His grandfather was a Blackfeet Indian.
- Miami Vice (1984) was produced by Michael Mann, Mykelti guest-starred in the pilot episode. They would later collaborate on Heat (1995) and Ali (2001) with Michael Mann as director.
- Friends with Denzel Washington.
- Has two daughters, with Sondra Spriggs, named Nicole and Maya.
- His other daughter, Phoenix, is from his marriage with Cheryl Chisholm.
- Invited to join AMPAS in 2005.
- Ex-brother-in-law of Steve Brown.
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