Khosi Ngema burst onto the scene with the 2020 Netflix release of "Blood and Water", about a local teen who uncovers her family's secret past and navigates the complicated world of a South African high school. In it she plays the lead role of "Fikile Bhele" opposite Ama Qamata, the other female lead.

Khosi is also an accomplished model, a talented singer and fluent in several languages including English.