Chiu first starred in the television series, Sana Maulit Muli (2007) which won her the year's Most Promising Female Star at GMMSF. This followed by a string of successful projects and leading roles in dramas such as the Philippine adaptation of My Girl (2008), action-melodramas Tayong Dalawa (2009), Kung Tayo'y Magkakalayo (2010), rom-com My Binondo Girl (2011-2012), family drama Ina, Kapatid, Anak (2012-2013) and period drama Ikaw Lamang (2014).

She also starred in several films including Bride for Rent (2014), the sixth highest grossing Filipino film of all time grossing P326 million at the box office. Her other high profile films include I Love You, Goodbye (2009) and Bakit Hindi Ka Crush Ng Crush Mo? (2013).

She has received a PMPC Award for Best Drama Actress, four FAMAS Award nominations (winning one) and was hailed Princess of Philippine Movies and TV for her accomplishments in the film and television industry.