Samuel G.C. Muñoz was born in Denver, CO and raised on the south side of Chicago, IL. He is the grandson to Irish German chemist George R. Wells, Mexican bullfighter Juan Jose Muñoz Lozada and is also of Spanish, French, English and Dutch ancestry.

Muñoz is known for his co-creation and performance, "2 Households 2 Assholes: Shakespeare's R & J" in New York City. His acting has been seen at the Tony Award winning Chicago Shakespeare Theater, Jeff Citation Award winning Defiant Theatre and Off Broadway.

Sam trained at Second City, National Theatre Conservatory, Columbia College Chicago School of Fine and Performing Arts, Florida Atlantic University Professional Acting Training Program, and with the Society of American Fight Directors.