The population of Twin Peaks was originally only supposed to be 5,120. However, there was a backlash against rural-themed shows at the time, as networks were fearful that the burgeoning urban and suburban population of America would not be able to sympathize with shows set in small farming or industrial towns, so ABC requested that the sign read 51,201. In a "Visitor's Guide to Twin Peaks" tie-in book authorized by creators David Lynch and Mark Frost, a note tells readers that the population was indeed 5,120, but that the sign had a "typo."

There are some episodes that don't end with the usual Homecoming Queen photo of Laura Palmer and "Laura Palmer's Theme" in the credits: Episode 2 credits feature the Little Man from Another Place seen from above and dancing. Episode 8 features Gersten Hayward (Alicia Witt) playing the piano. Episode 14 shows Agent Cooper, the red curtains and the song "The World Spins" by Julee Cruise. Episode 18 features Ben Horne's old home movies seen in this same episode. Episode 29 features the coffee cup given to Cooper in the Red Room and Laura's face on it.

Recent home media releases have removed the SPELLING logo from in-between the end credits and the Lynch/Frost Productions logo. This has caused the distinctive fall into the low-motif portion of the end credit theme ('Laura Palmer's Theme') during Season 1 to be lost, albeit it is partly retained in Season 2 due to the end credits being slightly extended and the low-motif portion beginning just as the credits section ends, rather than after.

Edited into What Happened to Her (2016)