After the cancellation of Port Charles several cast members transferred to General Hospital as new characters and this show's storylines were forgotten. Ten years later in 2013 General Hospital at last addressed this show when Lynn Herring's Lucy Coe mistook Kelly Monaco's Sam McCall for Livvie Locke and Michael Easton's John McBain for Easton's Port Charles Vampire King Caleb Morley (attempting to stake him in the heart with a wood chair leg). The show also reintroduced Erin Hershey Presley's Allison and answered the question of Alison's pregnancy which was left on a cliffhanger when Port Charles was cancelled.

Each 13-week arc of the story was referred to as a "book". There were a total of twelve books after the series switched to that format. In order, they were:

Fate December 4, 2000-March 2, 2001

Time in a Bottle March 5, 2001-June 1, 2001

Tainted Love June 4, 2001-August 31, 2001

Tempted September 3, 2001-November 30, 2001

Miracles Happen December 3, 2001-December 31, 2001

Secrets January 2, 2002-March 29, 2002

Superstition April 1, 2002-June 28, 2002

Torn July 1, 2002-September 27, 2002

Naked Eyes September 30, 2002-December 27, 2002

Surrender December 30, 2002-April 1, 2003

Desire April 2, 2003-July 4, 2003

The Gift July 7, 2003-October 3, 2003

Entertainment Weekly included the series on their list of "15 Soap Operas We've Loved, Lost" in their April 17, 2011 issue.

Lynne Herring and Wayne Northrop are married in real life and have worked together on screen before. Herring took a brief leave from her role of "Lucy" on GH to work on "Days of Our Lives," which starred Northrop as Roman Brady. The two also appeared as themselves in a movie of the week about Northrop's "Days" co-star Diedre Hall.

The final episode aired on October 3, 2003.