In 2001, 20th Century Fox sued Marvel Entertainment, stating "Mutant X" violated Fox's film rights for X-Men (2000). As a result, several changes to the premise of the series were made to distance it from the movie and its comic-book source material. Originally, the "mutant" characters were to have worn black costumes and used codenames (just as in X-Men), and Adam was to have been a wealthy mutant with the surname of Xero (similar to Professor Xavier). The show's logo was also changed from its initial design, which featured the "X" behind the word "Mutant," which resembled the logo used in trailers and TV ads for X-Men (2000) ("X" behind "Men").

When the show originally aired, it used a lot of licensed music. This was mostly changed for the DVD/streaming releases due to rights issues.

Referenced in The Cinema Snob: A Clockwork Orgy (2011)