According to screenwriter Guinevere Turner, while she was writing the first draft of the script, she received an angry phone-call from Director Uwe Boll, who swore at her and demanded she hand in a draft of the script. About a week later, after she sent in the rough first draft of the script, she was shocked to learn that production was going to commence immediately with the draft. (Even though traditionally the first draft is always a "rough" draft that is improved upon in subsequent drafts.) Later on, she was informed that Boll and the actors and actresses had subsequently re-written much of her script while shooting, and that the finished movie barely resembled her script.
Michael Madsen called this movie "an abomination, a horrifying and preposterous movie", but added that he enjoyed working with Director Uwe Boll and would certainly work with him again if asked.
The half-naked prostitutes in the scene with Leonid are real Romanian prostitutes. At the Stockholm International Film Festival, Director Uwe Boll said that prostitutes were cheaper to hire than actresses.
When asked in a 2007 interview with Time Magazine why an actor of his career and reputation would accept a role in this movie, Sir Ben Kingsley answered: "To be honest, I have always wanted to play a vampire, with the teeth and the long black cape. Let's say that my motives were somewhat immature for doing it."