Dr. Gregory House (Hugh Laurie) revels in solving the hardest of medical riddles. He chooses his team which changes over the years. Dr. Eric Foreman (Omar Epps), Dr. Robert Chase (Jesse Spencer), and Dr. Allison Cameron (Jennifer Morrison) are the three original underlings. Dr. James Wilson (Robert Sean Leonard) is his only true friend. Dr. Lisa Cuddy (Lisa Edelstein) starts as his boss.

Hugh is a British actor playing an American doctor who has a badly damaged leg. He's a grumpy caustic know-it-all. Too bad for everybody else, he is almost always right. He is inevitably the smartest man in the room. Oh did I mention that he's a drug addict. It's master acting class from Hugh. It's physical. It's accent work. It's character work. It's a great character.