As a traveler of sorts myself, I can say that I found this to be is a surprisingly well balanced documentary. The veteran psychonaught is unlikely to find anything here but a pleasant familiarity.
These kinds of drugs have enormous potential to help humanity. In fact, it's something we probably desperately need in these crazy times to help us connect to ourselves, our divinity and to each other.
However, the cautionary tales are essential, and responsible use is always encouraged. Personally I agree with String's advice on having an intention, and also Sting's decision to travel with the American Indian Shamans, as some these are substances are sacred medicines, or chemical variants of them. But not everyone has that opportunity.
I think the documentary would have been better if at least a little attention had been given to potentially tragic cases like Syd Barret, to give a completely fair analysis. But we don't really know what went on in his head. Maybe he was flying through space for eternity, maybe he was in heaven. We will never know. But on Earth he died a vegetable.
A positive spin is given at the end to the possibility of open study of these medicines by the Western methodology. This is good, but still miles behind the wisdom of traditional elders, who throughout the continents, have honed thousands of years of accumulated wisdom and safe guards. Western scientists may just grow a little if they pursue the study, as they will be forced to realise the yin and yang of that which can be measured and that which cannot.
The best recommendation I could give for safe travel is, if available, find a good Shaman and allow them to guide the journey. Unfortunately there are many charlatans out there. As such, personal recommendations are a sensible idea.
Be respectful, trust the heart, and love yourself and each another. Peace.