The film's producer is Malek Akkad, who is the son of Moustapha Akkad, the producer of the original 1978 "Halloween." Moustapha Akkad was murdered, along with his daughter Rima (Malek's sister), in the terrorist bombing of an Amman, Jordan hotel in 2005. Jamie Lee Curtis has recounted how the first person she saw when she came to the set for the first day of filming the 2018 film was Malek, who she remembered as a 7 year-old child visiting the set during production of the original film. She added that seeing Malek for the first time since his father's death immediately brought her to tears.

As with the original Halloween (1978), Michael Myers is listed in the credits not as "Michael Myers", but "The Shape".

The song playing when the boy and his dad notice the bus crash is a western version of the song Laurie sings throughout the original movie. It can also be heard during the end credits.

The role of Allyson, Laurie's granddaughter, became somewhat of a coveted role. Multiple popular actresses including Lucy Hale and Emma Roberts met with Danny McBride to personally talk about the movie. However, the studio decided that they wanted to go back to the roots of the first movie and cast an unknown actress, similar to how Jamie Lee Curtis was cast in the original.

Jake Gyllenhaal helped convince Jamie Lee Curtis to reprise her role of Laurie Strode for the film. Jake Gyllenhaal is a family friend of Curtis' and is dubbed by her as an unofficial godson.