The first episode is confusing and scary because Chloe's personality is simply so foreign and her behavior so carelessly wicked. However, as one adjusts to the idea of Chloe, James, and June, the more affectionate one grows of them.
Chloe is the exciting NYC "it" girl with an amusingly self-absorbed celebrity BFF, James Van Der Beek. The story begins when June, a naive, hopeful girl, moves in as Chloe's new roommate. Throughout, June questions different aspects of Chloe's rejection of human qualities, and Chloe, in return, questions June's naiveté/boringness. Through Chloe, June learns to be a little more city-smart and life-savvy, and through June, Chloe takes baby steps towards humanization. While the framework may not strike as being particularly impressive, the situations and personalities employed in each installment are lovably whimsical, and surprisingly escape oversentimentality.
One should treat these characters truly as characters and accept that everything will be exaggerated, maybe stereotyped, though faintly resonating with reality. It will be helpful to have an idea and a humored opinion of New York City, Indiana/Midwest, American celebrities, and Japan to appreciate the humor of Don't Trust the B----.
This show is goofy, sassy, young, and charming, and for those who crave a short comedy series that's girly but not "too" girly, I recommend it a try. Don't Trust the B---- (and Luther - oh, Luther...), you are fabulous.