The Mindy Project was cancelled by FOX on May 6, 2015. It was picked up by Hulu a week later.

Chris Messina (Danny Castellano) played a small role in You've Got Mail (1998), a film that is frequently mentioned by Mindy (Mindy Kaling) and Danny throughout the show.

The role of Dr. Jean Fishman was written specifically for Niecy Nash.

Mindy Kaling named her character Mindy Lahiri after acclaimed Indian-American author Jhumpa Lahiri.

Chris Messina missed the shooting of four consecutive episodes in season four, because he was busy filming Live by Night (2016). Nevertheless, he did guest voices in each episode.