Dr. Oliver Wolf reluctantly accepts a job at Bronx General Hospital where he's forced to work with a team of interns as they treat a mother who can no longer recognize her children.
When a high school girls' basketball coach is faced with a debilitating illness, Dr. Wolf must help his patient reconnect with her body before it's too late; Ericka and Dana treat a frat boy who sees dragons.
A member of a biker gang seeks out Dr. Wolf's help as he grapples with life-threatening memory loss. The interns are tasked to help a young girl struggling with mysterious seizures.
When a bloody bride stumbles into Bronx General, Wolf goes to extreme measures in a race against the clock to save her and her missing husband. Ericka and Jacob must find a reason for their John Doe patient not to get transferred.
Dr. Wolf and their medical team undertake an unprecedented procedure: implanting a brain-computer interface into an unidentified patient's brain, pushing the boundaries of experimental treatment.