When George starts having a quarter-life crisis, he does what anyone would do - quit his stable job as a pharmacist in Florida, move to LA, and start a cannabis dispensary. But to make his dreams a reality, George will have to win the support of the only two people who can give his plan a shot at success - his ex-best friends, Marcus and Brandy.

A chance encounter at a nightclub presents George, Marcus, and Brandy with an unexpected business opportunity, but leaves George in a tricky situation. The trio throws a grand opening party for the ages, but things take a turn for the worse when a new controversy erupts.

Attempting to salvage their reputation, the Yes We Cannabis crew pulls out all the stops at a prominent cannabis convention, but gets more than they bargained for when a new competitor arises. George gets some unnerving news that throws him into a tailspin.

It's a Hail Mary. The Yes We Cannabis crew lands a highly coveted guest spot on a highly influential podcast hosted by weed connoisseur Jay Smoke (Method Man). But their friendship is pushed to the limits as old grievances get hashed out live on air.

George hosts his parents for Thanksgiving, but things get complicated when Brandy brings a surprise guest. Marcus starts to struggle with his identity.

As George braces himself for one of the most awkward dinners of all time, Brandy and Marcus investigate a viral campaign that threatens to take down their business.

Facing a potential PR disaster, George asks his ex-girlfriend Nicole for help. But old feelings die hard, and they have to decide if they should get back together or part ways for good.

After a run-in with the law, Marcus and George resort to desperate measures, and are forced to take an uncomfortable trip down memory lane.

Road Trip. The Yes We Cannabis crew heads to the countryside, chasing a business opportunity with an old contact. But things get out of hand when they realize they might be dealing with a cult.

The Yes We Cannabis crew gets news that threatens to end their business and friendship forever.