Five animatronic dinosaurs were created for this movie, unlike Jurassic World (2015), which only featured one. More animatronics were used due to the many various and closer interactions actors had with the dinosaurs. One scene was when Bryce Dallas Howard rode atop the sedated T-Rex.

(at around 1h 30 mins) Multiple human characters are sedated with animal tranquilizers, with Wu specifically naming the particular narcotic used as carfentanil at one point. Carfentanil is extremely potent and has a lethal human dose in the micrograms, meaning any human injected with a dinosaur-sized dosage of carfentanil should have experienced a quick and fatal respiratory failure. Wu and Owen recover fairly quickly and suffer no lingering side effects. Because the tranquilizer is so potent, real-world veterinarians who sedate heavy animals like elephants must be accompanied by assistants who can administer naloxone (the antidote) and provide artificial respiration.

Post-credits scene: Pteranodons are shown flying on the Las Vegas Strip.

The Italian version has three scenes trimmed for violence before submitting the film to the local censorship commissions. These are: 1) T-Rex inside a cage swallowing a goat 2) Indoraptor swallowing the bitten-off hand of Ken Wheatley) Ted Levine and then roaring his hat off. 3) T-Rex and Carnosaur ripping in two the body of Eli Mills (Rafe Spall)

Featured in Half in the Bag: 2017 Movie Catch-up: Part 1 (2018)