Silicon Valley tech titan James Bell enlists Dr. Walter Wallace, an exceptional veteran surgeon with a controversial past, to run his state-of-the-art hospital with an ultramodern approach to medicine.

When a young boy's legs are crushed after being pinned by a car, Malik is determined to use a revolutionary procedure using spider silk to save his limbs, while Zoe lobbies in favor of the safer route of amputation. Also, James, Walter and Talaikha care for Amelia, a young woman in dire need of a liver transplant, but they're puzzled by her resistance when they tell her the donor is her estranged father, Simon.

The team tries reconstructing a police officer's brain when he loses his memory in a car accident.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.

James persuades a hockey player with a severe spinal injury to undergo a risky surgery that could allow him to walk again.

Walter and the Bunker Hill surgeons must perfect a revolutionary remote surgery when someone on the International Space Station needs an emergency procedure. Also, the team uses social media to locate the source of an E. coli outbreak in town; Scott's secret past is revealed; and Zoe and Malik's flirtation heats up.

When a young leukemia patient comes to Bunker Hill in need of a miracle, James hopes a new t-cell cancer treatment will save her life, as her optimism inspires him to become a better person. Also, Malik and Zoe agree to go on a date just as James confesses his feelings to her, and Julianna's Christmas visit with Walter uncovers the strain in their long-distance marriage.

James and the surgeons of Bunker Hill try to make medical history with an organ transplant chain of 16 surgeries with donors and patients from all over the world.

A young man arrives at Bunkerhill seeking treatment for a drug-resistant form of AIDS. Dr. Wallace's daughter brings an infected friend to Bunkerhill. James discusses his feelings with Zoe.

When a woman arrives at Bunker Hill with a mysterious lung ailment, James is conflicted after he connects other respiratory cases in her area to possible contamination from a microchip factory owned by his hero, tech guru Douglas Prescott (David Paymer). Also, Walter and Zoe work to find why a young man can't walk despite his legs being in good condition, and Zoe becomes jealous of James's connection to Nina.

James and Zoe work to help a teenage girl (Jessica Garza) with a rare skin blistering disorder, employing radical treatments to heal her skin in time for her to attend her school prom. Also, as Louis Keating's GSS condition gets worse, James is tempted to use his experimental cure to save him. And Malik is jealous over the special connection between James and Zoe, while Zoe awkwardly meets James' new crush, Nina (Alexis Krause).

Talaikha and Malik treat Georgia Ray (Lindsey Gort), one of the world's biggest pop stars and friend of James's, for laryngeal cancer, but when gold particles and microsurgery reveal more cancer than expected, they incur the singer's wrath when her vocal chords and career are threatened. Also, Angie's mother reluctantly sees Scott as a patient when she thinks she may be ill, and James is discouraged when he thinks Louis Keating's GSS is getting worse.

Angie needs Scott's help when her mother will not agree to being treated by nano-bots; Walter, Malik and Zoe attempt to use suspended animation to save a graffiti artist; Juliana discovers James treated Louis Keating with an unapproved drug.