Malcolm McDowell said: "The visuals are extraordinary, original and unique. I came off the shoot really high on it. I'm really happy I did it. And I don't say that often. I really don't. But this time I can."

The story of She Will has themes director Charlotte Colbert says she has always been interested in within her practice and within her life. "How trauma blurs one's experience of reality and time, how nature holds so much solace, how everyone carries within them the muscle memory of those who came before and those who will come after, how the infinitely small, like a cell, contains the same patterns as the universe. How meaning and perspective and reality and time are all such fragile constructs that can break at any time. The genre of psychological horror seems to allow more artistic freedom than drama. It also at its heart fittingly captures those existential feelings."

On Rotten Tomatoes, the movie has an approval rating of 87% based on 61 reviews. The website's consensus reads: "More unsettling than truly scary, She Will casts a thoughtful, hypnotic spell made even stronger by its restrained approach and some strong performances."

Both Alice Krige and Malcolm McDowell have previously played villains in the Star Trek film franchise. McDowell played Dr. Tolian Soran in Star Trek: Generations (1994), and Krige played the Borg Queen in Star Trek: First Contact (1996).