Extended Data Fig. 11: Regulation of BA biosynthesis by BA-MCYs in vivo.
From: Host metabolism balances microbial regulation of bile acid signalling
a,b, Abundances of endogenously produced BAs in feces of mice administered CDCA-MCY or CDCA-d5-MCY daily for 14 days. Shown are individual amounts of CDCA-derived BAs (a) and CA-derived BAs (b) in feces. Data are mean ± s.e.m. with control (corn oil) (n = 7) and CDCA-MCY fed mice (n = 7 for CDCA-derived pathway and n = 3 for CA-derived pathway). P values were calculated using unpaired two-sided Student’s t-test with Welch’s correction. c, Total endogenously produced BAs in feces of ABX mice administered CDCA-d5-MCY. Shown are total amounts of BAs (n = 13 for control and n = 14 for CDCA-MCY fed mice). Data are mean ± s.e.m. P values were calculated using unpaired two-sided Student’s t-test with Welch’s correction. d,e, Abundances of CDCA-derived BAs (d) and CA-derived BAs (e) in liver of mice administered CDCA-MCY or CDCA-d5-MCY daily for 14 days. Data are mean ± s.e.m. with control (corn oil) (n = 6) and CDCA-MCY fed mice (n = 3 for CDCA-derived pathway and n = 7 for CA-derived pathway). P values were calculated using unpaired two-sided Student’s t-test with Welch’s correction. f,g, Abundances of CDCA-derived BAs (f) and CA-derived BAs (g) in serum of mice administered CDCA-MCY or CDCA-d5-MCY daily for 14 days. Data are mean ± s.e.m. with control (corn oil) (n = 6) and CDCA-MCY fed mice (n = 3 for CDCA-derived pathway and n = 7 for CA-derived pathway). P values were calculated using unpaired two-sided Student’s t-test with Welch’s correction.
