Extended Data Fig. 10: Histologic analysis of kidneys shows minimal toxicity due to long-term treatment with SRP-2001.
From: A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome
Representative images of haemotoxylin and eosin (HE) staining of sectioned kidneys from treated (n = 12) and untreated (n = 12) mice. Mice receiving long-term treatment with SRP-2001 developed irregular cortical surfaces (ic), degenerate tubules (dt) and basophilic granules (bg) in tubular epithelial cells. Two sections per tissue sample were analyzed.
