npj Systems Biology and Applications

Hybridizing mechanistic modeling and deep learning for personalized survival prediction after immune checkpoint inhibitor immunotherapy

Joseph D. Butner
Prashant Dogra
Zhihui Wang

Article 14 August 2024

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A multiscale model of immune surveillance in micrometastases gives insights on cancer patient digital twins

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Paul Macklin
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Immune digital twins for complex human pathologies: applications, limitations, and challenges

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Reinhard Laubenbacher
James A. Glazier
PerspectiveOpen Access30 Nov 2024
Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma

Suryadipto Sarkar
Anna Möller
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Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer

Hari Prasad
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npj Systems Biology and Applications has a 2-year impact factor of 3.5 (2023), article downloads of 306,030 (2023) and 2 days from submission to first editorial decision (median) in 2023.
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Hybridizing mechanistic modeling and deep learning for personalized survival prediction after immune checkpoint inhibitor immunotherapy

Featured

A multiscale model of immune surveillance in micrometastases gives insights on cancer patient digital twins

Immune digital twins for complex human pathologies: applications, limitations, and challenges

Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma

Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer

Announcements

npj Systems Biology and Applications Journal Metrics

Call for papers: Virtual human development

Call for papers: Methodological developments in systems

Call for papers on mathematical oncology

Browse articles

Enhancing yeast cell tracking with a time-symmetric deep learning approach

A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers

An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition

Gene regulatory network inference during cell fate decisions by perturbation strategies

Loss formulations for assumption-free neural inference of SDE coefficient functions

Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases

Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection

Deep learning for detecting and early predicting chronic obstructive pulmonary disease from spirogram time series

Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

Trending - Altmetric

Science jobs

Faculty Positions in Center of Bioelectronic Medicine, School of Life Sciences, Westlake University

Faculty Positions in School of Engineering, Westlake University

Group Leader/Researcher in DDLS Epidemiology and Biology of Infection

Join Us∣SUSTech Calls for Global Talent

Become an Assistant or Associate Research Professor (PSO) in Cellular, Molecular and Synaptic Neuros

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Immune digital twins for complex human pathologies: applications, limitations, and challenges

An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition

Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer

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