Biological sciences articles within Nature Physics

Featured

  • News & Views |

    In a cancer mouse model, wrinkling patterns in bladder-lining tissue differ from their healthy counterparts. Changes in tissue-mechanical properties that alter elastic buckling instabilities explain this observation.

    • Alexander Mietke

  • Measure for Measure |

    Living organisms and soft materials pose specific challenges to metrology, as Pavao Andričević and Hüsnü Aslan explain.

    • Pavao Andričević
    •  & Hüsnü Aslan

  • Article |

    Tissues eliminate unwanted cells through cell extrusion, but the factors determining whether these extuded cells live or die are not fully understood. Now force transmission across adherens junctions is shown to have a role in shaping their fate.

    • Lakshmi Balasubramaniam
    • , Siavash Monfared
    •  & Benoit Ladoux

  • Article
    | Open Access

    Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

    • Franziska L. Lampart
    • , Roman Vetter
    •  & Dagmar Iber

  • News & Views |

    The cell cortex consists of a chemical and a mechanical subsystem, but how energy is allocated between them is unknown. Now, measurements of the entropy production rate have revealed what determines the cell cortex’s energy budget.

    • Shashi Thutupalli

  • Article
    | Open Access

    Unicellular parasites, such as Toxoplasma gondii, can use different forms of gliding motions when infecting a host. These motility modes arise from the self-organizing properties of filamentous actin flow at the surface of these parasitic cells.

    • Christina L. Hueschen
    • , Li-av Segev-Zarko
    •  & Alexander R. Dunn

  • News & Views |

    A platform for imaging traction forces exerted by moving cells overcomes current reconstruction limitations. This technique has identified unknown migration dynamics of immune cells and resolved traction forces of single and multicellular systems.

    • Jennifer Patten
    •  & Karin Wang

  • Article |

    How cells manage the internal energetic budget to drive mechanical and chemical dynamics is still an open question. Now it is shown that the allocation of energy depends on the distance from thermodynamic equilibrium.

    • Sheng Chen
    • , Daniel S. Seara
    •  & Michael P. Murrell

  • News & Views |

    Understanding the mechanism of bacterial cell division is important in both fundamental and applied biology. Now, researchers have investigated the self-organization of cytoskeletal filaments and the role nematic ordering plays in cell division.

    • Zhixin Lyu

  • Editorial |

    In light of the recent Olympic and upcoming Paralympic Summer Games in Paris, we take a closer look at the physics of sports and how it helps athletes improve their performance.

  • News & Views |

    Migrating cell clusters exhibit finger-like protrusions at the front, attributed to leader cells physically dragging follower cells along. Now, an optogenetics experiment has shown that follower cells must also play a role in protrusion formation.

    • Chiu Fan Lee

  • Article |

    The ducts of many fluid-pumping organs feature cilia. Two structural parameters organize the different types of ducts into a continuous spectrum between ciliary carpet and flame designs depending on the fluid-pumping requirements.

    • Feng Ling
    • , Tara Essock-Burns
    •  & Eva Kanso

  • News & Views |

    Experiments show that the shape of a biofilm, not just its cell doubling time, significantly impacts its expansion rate. This insight could guide new strategies for controlling biofilm growth.

    • Hudson Borja da Rocha
    •  & Tal Cohen

  • Article |

    The growth of a biofilm—a bacterial colony attached to a surface—is governed by a trade-off between horizontal and vertical expansion. Now, it is shown that this process significantly depends on the contact angle at the biofilm’s edge.

    • Aawaz R. Pokhrel
    • , Gabi Steinbach
    •  & Peter J. Yunker

  • Article |

    A multiscale model of muscle as a fluid-filled sponge suggests that hydraulics limits rapid contractions and that the mechanical response of muscle is non-reciprocal.

    • Suraj Shankar
    •  & L. Mahadevan

  • News & Views |

    Spatial heterogeneity in disease transmission rates and in mixing patterns between regions makes predicting epidemic trajectories hard. Quantifying the mixing rates within and between spatial regions can improve predictions.

    • Emily Paige Harvey
    •  & Dion R. J. O’Neale

  • Article |

    Supracellular cues play a key role in directing collective cell migration in processes such as wound healing and cancer invasion. New findings emphasize the importance of all length scales of the microenvironment in shaping cell migration patterns.

    • Mathilde Lacroix
    • , Bart Smeets
    •  & Pascal Silberzan

  • News & Views |

    A clear picture of how and why cells inevitably lose viability is still lacking. A dynamical systems view of starving bacteria points to a continuous energy expenditure needed for maintaining the right osmotic pressure as an important factor.

    • Ann Xu
    •  & Hyun Youk

  • Article |

    Active cell contraction drives hole nucleation, fracture and crack propagation in a tissue monolayer through a process reminiscent of dewetting thin films.

    • Jian-Qing Lv
    • , Peng-Cheng Chen
    •  & Bo Li

  • Research Briefing |

    The nuclear pore complex of eukaryotic cells senses the mechanical directionality of translocating proteins, favouring the passage of those that have a leading mechanically labile region. Adding an unstructured, mechanically weak peptide tag to a translocating protein increases its rate of nuclear import and accumulation, suggesting a biotechnological strategy to enhance the delivery of molecular cargos into the cell nucleus.

  • Perspective |

    Encouraging students to take ownership of their learning can improve their outcomes. This Perspective discusses ways to achieve this in the context of physics education and how digital technology can help Gen Z students in particular.

    • Nam-Hwa Kang

  • Perspective |

    Quantum computers promise to efficiently predict the structure and behaviour of molecules. This Perspective explores how this could overcome existing challenges in computational drug discovery.

    • Raffaele Santagati
    • , Alan Aspuru-Guzik
    •  & Clemens Utschig-Utschig

  • Article |

    Cytoplasmic flows in the fruit fly oocyte can reorganize cellular components. These structured vortical flows arise through self-organizing dynamics of microtubules, molecular motors and cytoplasm.

    • Sayantan Dutta
    • , Reza Farhadifar
    •  & Michael J. Shelley

  • Research Briefing |

    Studies of a biological active nematic fluid reveal a spontaneous self-constraint that arises between self-motile topological defects and mesoscale coherent flow structures. The defects follow specific contours of the flow field, on which vorticity and strain rate balance, and hence, contrary to expectation, they break mirror symmetry.

  • Article |

    The strengths of connections in networks of neurons are heavy-tailed, with some neurons connected much more strongly than most. Now a simple network model can explain how this heavy-tailed connectivity emerges across four different species.

    • Christopher W. Lynn
    • , Caroline M. Holmes
    •  & Stephanie E. Palmer

  • Article |

    Although using low-rank matrices is the go-to approach to model the dynamics of complex systems, its validity remains formally unconfirmed. An analysis of random networks and real-world data now sheds light on this low-rank hypothesis and its implications.

    • Vincent Thibeault
    • , Antoine Allard
    •  & Patrick Desrosiers

  • News & Views |

    Cells actively rearrange their cytoplasmic machinery to perform diverse functions. Now, friction forces generated between cytoplasmic components provide a physical basis for cell shape change.

    • Toby G. R. Andrews
    •  & Rashmi Priya

  • News & Views |

    Orderly or coherent multicellular flows are fundamental in biology, but their triggers are not understood. In epithelial tissues, the tug-of-war between cells is now shown to lead to intrinsic asymmetric distributions in cell polarities that drive such flows.

    • Guillermo A. Gomez

  • Editorial |

    Many advances in biological physics result from multidisciplinary collaborations. We celebrate the physics of life with a collection of articles that offer insight into successful interactions between researchers from different fields.

  • Comment |

    Macroscale analogies are a powerful conceptual tool with which we can gain insight into the structures and processes of the microscopic world of cell biology.

    • Michelle A. Baird

Browse narrower subjects

Browse Biological sciences across other nature.com journals