Insights into how cholesterol-carrying low-density lipoproteins are structured, and how they interact with receptors to enter cells, could help to clarify the role of these particles in cardiovascular disease.

Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.

The origins of mammalian lymphatic vessels have been debated since the early twentieth century; recent data are shifting the balance toward a less widely accepted view.

Jin et al. identified PKN1 as the kinase responsible for histone phosphorylation-mediated FOS/FOSB induction and vessel inflammation in regions of disturbed blood flow, highlighting an additional regulation layer for atherosclerotic plaque development.

In this Review, the authors examine the diuretic drug class and its use in the treatment of hypertension and volume overload in chronic kidney disease, including dosage and mode of administration. The authors also discuss the mechanisms underlying diuretic resistance and its management, including the use of combination therapy.

Insights into how cholesterol-carrying low-density lipoproteins are structured, and how they interact with receptors to enter cells, could help to clarify the role of these particles in cardiovascular disease.

Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.

The origins of mammalian lymphatic vessels have been debated since the early twentieth century; recent data are shifting the balance toward a less widely accepted view.

Clonal hematopoiesis of cells carrying an ASXL1 mutation promotes atherosclerosis. An unexpected function of ASXL1 — direct inhibition of IL-1 receptor and Toll-like receptor signaling — was lost by ASXL1 mutation, leading to prolonged inflammation. IRAK inhibitors reduced the atherosclerotic plaque size, implicating IRAK inhibitors in the therapies of cardiovascular diseases driven by ASXL1-associated clonal hematopoiesis.

Two studies presented at AHA 2024 Scientific Sessions describe the efficacy and safety of left atrial appendage closure after catheter ablation for atrial fibrillation and the 5-year outcomes of the largest randomized left atrial appendage closure trial to date comparing the safety and efficacy of two devices.