Mathematical modelling suggests that it is theoretically possible to reduce risk of common diseases using heritable genome editing. Scientists argue that the technology involves considerable risk and uncertain benefits.

A novel in vivo screening strategy identifies new modifiers of somatic CAG repeat expansion that contribute to age of onset in Huntington’s disease.

Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in mice, and propose the therapeutic exploration of nickases.

Although compact Un1Cas12f1 has improved, low gene editing activity was observed in some target genes. Here, authors developed eCas12f1, which exhibits similar cleavage activity to SpCas9 and can be effectively applied in targeted therapy, demonstrating its potential as a powerful gene editing tool.

The trans-Tango genetic strategy, which mediates signaling across synapses, was adapted to identify neural connections in a vertebrate nervous system, with synaptic partners confirmed in the retina and spinal cord of larval zebrafish.

Lab-grown viruses make cancer cells resemble pig tissue, provoking an organ-rejection response.

Mathematical modelling suggests that it is theoretically possible to reduce risk of common diseases using heritable genome editing. Scientists argue that the technology involves considerable risk and uncertain benefits.

Gene-editing technologies for cancer and blood disorders are maturing a little more than a year after the first CRISPR drug was approved.

Scientists in Asia and Africa are racing to discover hardier crop varieties using gene editing tools. But patent restrictions come in the way.

CRISPR screens are untangling molecular mechanisms that drive biological processes with greater precision and detail.