Evidence suggests that anthropogenic climate change is accelerating, with serious consequences for human health. This Perspective explores how the effects of climate change, such as extreme temperatures, altered weather patterns and increased air pollution, interact with the brain, and discusses how neurologists can respond constructively to the climate crisis.

In this Tools of the Trade article, Birch describes how extracellular vesicles can be engineered to deliver therapeutic microRNAs for the treatment of ischaemic stroke.

Acute ischaemic stroke induces persistent innate immune memory through epigenetic changes in myeloid progenitors in the bone marrow, and this innate immune training contributes to cardiac remodelling and dysfunction in the long term, according to a new study.

Rare and common variants in HTRA1 are associated with ischemic stroke. Research now sheds light on the underlying genetic architecture and suggests a vasculopathy with a broader phenotypic spectrum. Lower HTRA1 protease activity and circulating levels both predict an increased risk of ischemic stroke and coronary artery disease.