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Bioscience

Gene delivery systems

The Research

viral vector illustration with RNA seen within the capsid

Gene Delivery Particle Analysis with High-Throughput Light Scattering Microscopy

Ongoing

This project aims to develop light-scattering microscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable

High-Sensitivity IR Spectroscopy of Proteins

Ongoing

Infrared (IR) absorption spectroscopy has been widely used as a non-invasive, label-free characterization method for the chemical identification and structure of complex biomolecules. Fourier-transform IR (FT-IR) technology is commonly used to characterize proteins and other biological molecules

Gene Delivery Systems

Ongoing

Viral Vectors Viral vectors are a critical tool for delivering DNA or RNA into patient’s cells. Common viral vectors for gene therapy include adenovirus, lentivirus, and adeno associated virus. Administration of viral vectors can occur in vivo or ex vivo , such as for adeno associated virus or

Flow Cytometry Consortium

NIST Flow Cytometry Standards Consortium 

Ongoing

Advances in cell and gene-based therapeutics as well as other regenerative medicine products have increased the need for high quality, robust, and validated measurements for cell characterization. Flow cytometry, including imaging cytometry, has emerged as an important platform due to its ability to

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