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    Pancrease Benign Tumors

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    Valerie Gonzaga-Carandang
    This document discusses two types of benign pancreatic tumors: serous cystadenoma and mucinous cystadenoma. Serous cystadenomas are very rare, slow-growing tumors that are often asymptomatic and incidental findings. Mucinous cystadenomas have a higher risk of malignant transformation at 6-36% and commonly present in middle-aged women. Both types can be identified through imaging showing characteristic cystic masses and fluid analysis. Surgical resection is the treatment for symptomatic or growing tumors to prevent complications and remove potentially cancerous mucinous cystadenomas.

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    Pancrease Benign Tumors

    Uploaded by

    Valerie Gonzaga-Carandang
    24 views8 pages
    This document discusses two types of benign pancreatic tumors: serous cystadenoma and mucinous cystadenoma. Serous cystadenomas are very rare, slow-growing tumors that are often asymptomatic and incidental findings. Mucinous cystadenomas have a higher risk of malignant transformation at 6-36% and commonly present in middle-aged women. Both types can be identified through imaging showing characteristic cystic masses and fluid analysis. Surgical resection is the treatment for symptomatic or growing tumors to prevent complications and remove potentially cancerous mucinous cystadenomas.

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    This document discusses two types of benign pancreatic tumors: serous cystadenoma and mucinous cystadenoma. Serous cystadenomas are very rare, slow-growing tumors that are often asymptomatic and incidental findings. Mucinous cystadenomas have a higher risk of malignant transformation at 6-36% and commonly present in middle-aged women. Both types can be identified through imaging showing characteristic cystic masses and fluid analysis. Surgical resection is the treatment for symptomatic or growing tumors to prevent complications and remove potentially cancerous mucinous cystadenomas.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    24 views8 pages

    Pancrease Benign Tumors

    Uploaded by

    Valerie Gonzaga-Carandang
    This document discusses two types of benign pancreatic tumors: serous cystadenoma and mucinous cystadenoma. Serous cystadenomas are very rare, slow-growing tumors that are often asymptomatic and incidental findings. Mucinous cystadenomas have a higher risk of malignant transformation at 6-36% and commonly present in middle-aged women. Both types can be identified through imaging showing characteristic cystic masses and fluid analysis. Surgical resection is the treatment for symptomatic or growing tumors to prevent complications and remove potentially cancerous mucinous cystadenomas.

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    Non-Endocrine Neoplasm

    Benign Tumors

    Serous Cystadenoma

    Benign tumors without malignant potential


    Very rare (<1%)
    Mass effect or rapid growth
    0.45 cm/year average rate of growth
    Asymptomatic and incidental finding 50%
    Symptomatic:
    mild upper abdominal pain, epigastric fullness, or moderate weight
    loss
    can grow to a size capable of producing jaundice or GI obstruction
    due to mass effect surgical resection

    Frequently in older women in which pancreatic resection for a


    benign neoplasm should be avoided in the absence of
    significant symptoms.
    All regions of the pancreas are affected.

    Serous Cystadenoma
    Spongy appearance, microcystic> macrocystic
    Thin serous fluid that does not stain positive for
    mucin and is low in CEA (<200 ng/mL)
    Typical imaging characteristics:
    well-circumscribed cystic mass
    small septations
    fluid close to water density
    central scar with calcification

    EUS-FNA
    Nonviscous fluid with low CEA and amylase levels,
    Cells are obtained: cuboidal and have a clear cytoplasm.

    Mucinous Cystadenoma
    Benign but potentially malignant
    carcinoma with a very aggressive behavior
    6% to 36% - reported to be malignant
    Commonly seen in perimenopausal
    women
    2/3 are located in the body or tail of the
    pancreas.
    Incidental finding
    Nonspecific symptoms: upper abdominal
    discomfort or pain, early satiety, and weight
    loss

    Mucinous Cystadenoma
    Imaging studies
    The cysts have thick walls and do not
    communicate with the main pancreatic duct
    Nodules or calcifications within the wall of the
    cyst
    Cysts are lined by tall columnar epithelium
    that fills the cyst with viscous mucin
    Submucosal layer consists of a highly cellular
    stroma of spindle cells with elongated nuclei
    Elevated CEA levels in the fluid (>200 ng/mL)
    may suggest malignant transformation.

    Mucinous Cystadenoma
    Resection is the treatment of choice: distal pancreatectomy
    Malignant transformation more common with
    larger tumors
    older patients
    stepwise accumulation of mutations (K-ras, p53)
    Small lesions
    preserve the spleen
    splenectomy ensures removal of the lymph node basin
    Important not to rupture the cyst during resection and the tumor
    should be removed intact, not morselized.
    Prognosis
    Complete resection, without atypia, small (<3cm) cured
    Complete resection with moderate dysplasia or CIST- cured
    Invasive carcinoma, mucinous cystadenocarcinoma - dismal

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