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    Pathophysiology: Predisposing Factors Precipitating Factors

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    rozj07
    This patient has a history of gout attacks over 30 years. Predisposing factors include a high purine diet, smoking, alcohol consumption, and a family history of gout. Precipitating factors for this current attack include age, gender, and dehydration from alcohol use. Elevated uric acid levels cause urate crystals to deposit in joints and kidneys, triggering an inflammatory response and resulting in swelling, pain, and loss of motion in this patient's ankles, wrists, fingers and elbows.

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    Pathophysiology: Predisposing Factors Precipitating Factors

    Uploaded by

    rozj07
    247 views1 page
    This patient has a history of gout attacks over 30 years. Predisposing factors include a high purine diet, smoking, alcohol consumption, and a family history of gout. Precipitating factors for this current attack include age, gender, and dehydration from alcohol use. Elevated uric acid levels cause urate crystals to deposit in joints and kidneys, triggering an inflammatory response and resulting in swelling, pain, and loss of motion in this patient's ankles, wrists, fingers and elbows.

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    Pa Tho Physiology

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    This patient has a history of gout attacks over 30 years. Predisposing factors include a high purine diet, smoking, alcohol consumption, and a family history of gout. Precipitating factors for this current attack include age, gender, and dehydration from alcohol use. Elevated uric acid levels cause urate crystals to deposit in joints and kidneys, triggering an inflammatory response and resulting in swelling, pain, and loss of motion in this patient's ankles, wrists, fingers and elbows.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    247 views1 page

    Pathophysiology: Predisposing Factors Precipitating Factors

    Uploaded by

    rozj07
    This patient has a history of gout attacks over 30 years. Predisposing factors include a high purine diet, smoking, alcohol consumption, and a family history of gout. Precipitating factors for this current attack include age, gender, and dehydration from alcohol use. Elevated uric acid levels cause urate crystals to deposit in joints and kidneys, triggering an inflammatory response and resulting in swelling, pain, and loss of motion in this patient's ankles, wrists, fingers and elbows.

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    PATHOPHYSIOLOGY

    PRECIPITATING FACTORS PREDISPOSING FACTORS


    AGE: 56 YEARS OLD
    GENDER: MALE
    FAMILY HISTORY OF GOUT
    30 YEARS OF GOUT ATTACK LIQOUR DRINKER 4-5 bottles/day(Tanduay)
    SMOKES 3 PACKS OF CIGARETTE/DAY
    HIGH PURINE DIET
    (sea foods, beans, meats such as liver)

    Increase Uric acid level in the blood stream

    Monosodium urate deposition

    Kidney Joints
    Urinalysis
    pH=5.0
    Decrease uric acid excretion A pH of 5 enhances
    >Monosodium and allowsaturate
    urate precipitates deposition
    the periphery of the body, where lower body temperatures may re

    > Decrease in pH which enhances urate deposition

    Deposition in renal interstitial tissue


    Ultrasound

    Small Non-obstructing left nephrolithiasis probably low density crystals

    Impaired urine flow


    Tophi (deposits of urate crystals) in the skin and cartilages

    Nephrolithiasis on left kidney

    Left flank pain

    Activation of polymorphonuclear cells Activates white blood cells

    elease of Prostaglandins and leukotrienes Hematology Release of inflammatory poteinase and prostano
    WBC: 16.9 x 9/L having a normal value of 4.5-11.0

    Destruction of cartilage and bones

    Inflammatory response

    >swelling, heat, redness, pain in ankle and tarsal area


    >bilateral stiffness of tarsals and wrists
    >presence of enlargement (lumps) of joints in tarsal area, ankle, wrist, fingers and elbow
    >some enlarged joints on left foot (tarsal, ankle) drains to a crystalline deposits (tophi)
    >(+) loss of joint motions in fingers, wrist, ankle and tarsal area

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