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    Beta Thalassemia Patho

    Uploaded by

    Angie Lamo
    Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that results in abnormal hemoglobin production and red blood cell dysfunction. Predisposing factors include familial predisposition and Southeast Asian ancestry. The mutation prevents normal beta chain formation in hemoglobin, causing red blood cells to become smaller and die more easily, leading to anemia, enlarged spleen, weakness, and other symptoms as the body tries to compensate.

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    Beta Thalassemia Patho

    Uploaded by

    Angie Lamo
    115 views1 page
    Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that results in abnormal hemoglobin production and red blood cell dysfunction. Predisposing factors include familial predisposition and Southeast Asian ancestry. The mutation prevents normal beta chain formation in hemoglobin, causing red blood cells to become smaller and die more easily, leading to anemia, enlarged spleen, weakness, and other symptoms as the body tries to compensate.

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    beta thalassemia patho

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    Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that results in abnormal hemoglobin production and red blood cell dysfunction. Predisposing factors include familial predisposition and Southeast Asian ancestry. The mutation prevents normal beta chain formation in hemoglobin, causing red blood cells to become smaller and die more easily, leading to anemia, enlarged spleen, weakness, and other symptoms as the body tries to compensate.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    115 views1 page

    Beta Thalassemia Patho

    Uploaded by

    Angie Lamo
    Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that results in abnormal hemoglobin production and red blood cell dysfunction. Predisposing factors include familial predisposition and Southeast Asian ancestry. The mutation prevents normal beta chain formation in hemoglobin, causing red blood cells to become smaller and die more easily, leading to anemia, enlarged spleen, weakness, and other symptoms as the body tries to compensate.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Predisposing Factors: Precipitating Factor:

    With familial predisposition Mutation of HBB gene on


    Southeast Asian Ancestry chromosome 11
    Age less than 10

    Prevention of beta chain formation of


    hemoglobin

    Abnormal decrease in
    the hemoglobin RBC malfunctions RBC dies easily
    content of
    erythrocytes

    RBC becomes smaller Spleen compensate


    Poor blood and oxygen
    than normal erythrocytes by over-functioning
    supply to the parts of
    the body

    Spleen enlarges
    Cells metabolize Heart will Lungs will
    (spleenomegaly)
    aerobically compensate compensate

    It traps blood cells as


    it enlarge
    Increase pumping in Increase rate of
    an attempt to respiration
    supply blood in all Damage to the spleen
    parts of the body occurs

    Hypochromia Weakness and Tachycardia Tachypnea Anemia Micro Bleeding


    fatigue cytosis

    Beta- Thalassemia

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